Tangerines' Nobiletin: Protect Against Coronary Artery Disease

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Do You Know That Tangerines May Protect the Body From Coronary Artery Disease?

An article on Everyday Health.com highlights the metabolic benefits of tangerines, labeling them as metabolic masters.

Research from the University of Western Ontario, as reported in Science Daily, suggests that a flavonoid, a type of antioxidant found in this citrus fruit, may provide protection against the trio of diseases collectively known as metabolic syndrome — coronary artery disease, stroke, and type 2 diabetes. In experiments where mice were fed a typical “western” diet (high in fat and refined sugar) supplemented with the tangerine antioxidant nobiletin, the mice experienced no increase in cholesterol, triglycerides, insulin, or blood sugar. Conversely, mice without nobiletin supplementation saw a rise in these factors. Additionally, long-term animal studies have indicated that this compound prevents atherosclerosis, the hardening of arteries linked to heart attacks or strokes.

Tangerines may also play a role in cancer prevention when the peel is consumed. A British study discovered that a compound in the peel, salvestrol Q40, inhibits the activity of an enzyme that stimulates the growth of cancer cells. To incorporate the benefits, try adding tangerine zest to your tea or sprinkle it on a salad for a citrusy twist.

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Dr. Willian Julien
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Dr. Julien has performed more than 40,000 vascular procedures across a 30-year career. Double board-certified in Interventional Radiology and Diagnostic Radiology by the American Board of Radiology, he is the co-founder and past president of the Outpatient Endovascular & Interventional Society, a national faculty speaker at SIR, TCT, VIVA, and the Southeastern Angiographic Society, and a published author. Named a Boca Magazine Top Doctor 2025.

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